Professor of Bone Research, NHMRC Senior Research Fellow, Head of Bone Growth and Repair Research Group (University of South Australia)
Nanomedicine; nanotechnology for bone/cartilage repair
BAgSci (1985, Guangzhou, China)
MSci (1990, Armidale, Australia)
PhD (1993, Perth, Australia)
Prof Cory Xian is a NHMRC Senior Research Fellow and Professor of Bone
Research at University of South Australia (http://people.unisa.edu.au/Cory.Xian).
He is interested in tissue growth and injury repair research. He has
considerable strengths in leading successful and productive research in
areas of tissue growth, injury and repair, and roles of growth factors and
stem cells. He leads The Bone Growth and Repair Research Group (currently 13
members composed of postdoctoral researchers, visiting research scientists,
and PhD and honours students). Prof Xian is also the Bone Growth Research
Program Leader for Children's Research Centre (University of Adelaide). He
serves as a member of Bone Growth Foundation Research Committee (Australia)
and a member for Channel-7 Children's Research Foundation of South
Australia, and has editorial board memberships for 5 international
scientific journals and is Managing Editor for Frontiers in Bioscience.
Prof Xian graduated from South China Agricultural University in 1985
(Guangzhou, B.Ag.Sci in Animal & Vet Sciences) and obtained his MSci degree
(Nutritional Biochemistry) from University of New England (1990, Armidale,
Australia) and PhD (Biochemistry/Immunology) from Murdoch University (1993,
Perth, Australia). His earlier research positions include those at Child
Health Research Institute (1992-1998), University of North Carolina at
Chapel Hill (1999), Flinders University (2000-2001), Women’s and Children’s
Hospital with strong affiliation with The University of Adelaide
(2002-2007).
Current research interests
● Bone growth mechanisms, regulation and intervention;
● Mechanisms for injury responses and bone growth defects after growth plate fracture;
● Development of biological treatments (growth factors, stem cells, and/or novel material-based) for repairing injured growth plate cartilage and fractured bone;
● Mechanisms for cancer chemotherapy-induced bone growth arrest and osteoporosis and development of preventative treatments.
Zhou FH, BK Foster, XF Zhou, CJ Xian (2006). TNF-alpha mediates p38 MAP
kinase activation and negatively regulates bone formation at the growth
plate injury site in rats. Journal of Bone and Mineral Research 21,
1075-1088
Xian CJ and BK Foster (2006). Repair of injured articular and growth plate
cartilage using mesenchymal stem cells and chondrogenic gene therapy.
Current Stem Cell Research and Therapy 1, 213-229 (Invited review)
McCarty RC, Gronthos S, Zannettino AC, Foster BK, Xian CJ (2009).
Characterisation and Developmental Potential of Ovine Bone Marrow Derived
Mesenchymal Stem Cells. Journal of Cellular Physiology. 219: 324-33
Xian CJ and Zhou X-F (2009). Treating skeletal pain: limitations of
conventional anti-inflammatory drugs and anti-neurotrophic factor as a
possible alternative. Nature Reviews Rheumatology 5, 92-98 (Invited
review)
Georgiou KR, Foster BK, Xian CJ (2010). Damage and Recovery of the Bone
Marrow Microenvironment Induced by Cancer Chemotherapy – Potential
Regulatory Role of Chemokine CXCL12/Receptor CXCR4 Signalling. Current
Molecular Medicine (in press)
Xian CJ (2010). Mechanisms of bony repair at the injured growth plate
cartilage. in Bone Regeneration: Growth Factors, Augmentation Procedures and
Tissue Engineering Applications (ed V. Legard), (Nova Science
Publishers, Inc, 2010).